Ontology highlight
ABSTRACT:
SUBMITTER: Chang JC
PROVIDER: S-EPMC2725594 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Chang Jennifer C JC Miner Maurine D MD Pandey Amit K AK Gill Wendy P WP Harik Nada S NS Sassetti Christopher M CM Sherman David R DR
Journal of bacteriology 20090619 16
Recently, cholesterol was identified as a physiologically important nutrient for Mycobacterium tuberculosis survival in chronically infected mice. However, it remained unclear precisely when cholesterol is available to the bacterium and what additional bacterial functions are required for its metabolism. Here, we show that the igr locus, which we previously found to be essential for intracellular growth and virulence of M. tuberculosis, is required for cholesterol metabolism. While igr-deficient ...[more]