Unknown

Dataset Information

0

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.


ABSTRACT: Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against Mtb. To unveil the underlying mechanism of IL-36 induced antibacterial activity, we analyzed its role in the regulation of cholesterol metabolism, together with the involvement of Liver X Receptor (LXR) in this process. We report that, in Mtb-infected macrophages, IL-36 signaling modulates cholesterol biosynthesis and efflux via LXR. Moreover, IL-36 induces the expression of cholesterol-converting enzymes and the accumulation of LXR ligands, such as oxysterols. Ultimately, both IL-36 and LXR signaling play a role in the regulation of antimicrobial peptides expression and in Mtb growth restriction. These data provide novel evidence for the importance of IL-36 and cholesterol metabolism mediated by LXR in cellular host defense against Mtb.

SUBMITTER: Ahsan F 

PROVIDER: S-EPMC5784124 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.

Ahsan Fadhil F   Maertzdorf Jeroen J   Guhlich-Bornhof Ute U   Kaufmann Stefan H E SHE   Moura-Alves Pedro P  

Scientific reports 20180124 1


Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against Mtb. To unveil the underlying mechanism of IL-36 induced antibacterial activity, we analyzed its role in the regulation of cholesterol metabolism, together with the involvement of Liver X Receptor (L  ...[more]

Similar Datasets

2018-02-14 | GSE103092 | GEO
| S-EPMC2725594 | biostudies-literature
| S-EPMC5089371 | biostudies-literature
| S-EPMC2771735 | biostudies-literature
| S-EPMC7181847 | biostudies-literature
| S-EPMC2804191 | biostudies-literature
| S-EPMC5428333 | biostudies-literature
| S-EPMC5479636 | biostudies-literature
| S-EPMC2824837 | biostudies-literature
2020-11-05 | GSE135952 | GEO