Ontology highlight
ABSTRACT:
SUBMITTER: Ahsan F
PROVIDER: S-EPMC5784124 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ahsan Fadhil F Maertzdorf Jeroen J Guhlich-Bornhof Ute U Kaufmann Stefan H E SHE Moura-Alves Pedro P
Scientific reports 20180124 1
Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against Mtb. To unveil the underlying mechanism of IL-36 induced antibacterial activity, we analyzed its role in the regulation of cholesterol metabolism, together with the involvement of Liver X Receptor (L ...[more]