Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC2771735 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Yang Xinxin X Nesbitt Natasha M NM Dubnau Eugenie E Smith Issar I Sampson Nicole S NS
Biochemistry 20090501 18
Mycobacterium tuberculosis can metabolize cholesterol to both acetate and propionate. The mass of isolated phthiocerol dimycoserate, a methyl-branched fatty acylated polyketide, was used as a reporter for intracellular propionate metabolic flux. When M. tuberculosis is grown using cholesterol as the only source of carbon, a 42 amu increase in average phthiocerol dimycoserate molecular weight is observed, consistent with the cellular pool of propionate and, thus, methylmalonyl CoA increasing upon ...[more]