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Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.

ABSTRACT: Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of cellular motors. Moreover, advances have been made in understanding cellular functions of SD-RRs beyond chemotaxis. We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases.

SUBMITTER: Jenal U

PROVIDER: S-EPMC2725762 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.

Jenal Urs U Galperin Michael Y MY

Current opinion in microbiology 20090224 2

Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of c ...[more]

PMID: 19246239

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