Ontology highlight
ABSTRACT:
SUBMITTER: Lundmark R
PROVIDER: S-EPMC2726289 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Lundmark Richard R Doherty Gary J GJ Howes Mark T MT Cortese Katia K Vallis Yvonne Y Parton Robert G RG McMahon Harvey T HT
Current biology : CB 20081101 22
Clathrin-independent endocytosis is an umbrella term for a variety of endocytic pathways that internalize numerous cargoes independently of the canonical coat protein Clathrin [1, 2]. Electron-microscopy studies have defined the pleiomorphic CLathrin-Independent Carriers (CLICs) and GPI-Enriched Endocytic Compartments (GEECs) as related major players in such uptake [3, 4]. This CLIC/GEEC pathway relies upon cellular signaling and activation through small G proteins, but mechanistic insight into ...[more]