Ontology highlight
ABSTRACT:
SUBMITTER: Saint Fleur S
PROVIDER: S-EPMC2727414 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Saint Fleur Shella S Hoshino Akemi A Kondo Kimie K Egawa Takeshi T Fujii Hodaka H
Blood 20090615 7
Activation-induced cell death (AICD) plays an essential role in the contraction of activated T cells after eradication of pathogen. Fas (APO-1/CD95) is one of the key cell surface proteins that mediate AICD in CD4(+) and CD8(+) T cells. Despite its prime importance in cell death, regulation of Fas expression in T cells is poorly understood. Here we show that Cyclon, a newly identified cytokine-inducible protein, is induced in T cells on T-cell receptor ligation and important for immune homeostas ...[more]