Ontology highlight
ABSTRACT:
SUBMITTER: Guo HL
PROVIDER: S-EPMC3411167 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Guo Hui-Ling HL Zhang Cixiong C Liu Qi Q Li Qinxi Q Lian Guili G Wu Di D Li Xuebin X Zhang Wei W Shen Yuemao Y Ye Zhiyun Z Lin Shu-Yong SY Lin Sheng-Cai SC
Cell research 20120403 8
Insulin-stimulated glucose uptake by the glucose transporter GLUT4 plays a central role in whole-body glucose homeostasis, dysregulation of which leads to type 2 diabetes. However, the molecular components and mechanisms regulating insulin-stimulated glucose uptake remain largely unclear. Here, we demonstrate that Axin interacts with the ADP-ribosylase tankyrase 2 (TNKS2) and the kinesin motor protein KIF3A, forming a ternary complex crucial for GLUT4 translocation in response to insulin. Specif ...[more]