Neuronal release of proBDNF.
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ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC2737352 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Neuronal release of proBDNF.
Yang Jianmin J Siao Chia-Jen CJ Nagappan Guhan G Marinic Tina T Jing Deqiang D McGrath Kelly K Chen Zhe-Yu ZY Mark Willie W Tessarollo Lino L Lee Francis S FS Lu Bai B Hempstead Barbara L BL
Nature neuroscience 20090111 2
Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB. ...[more]
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