Ontology highlight
ABSTRACT:
SUBMITTER: Pooler AM
PROVIDER: S-EPMC3615658 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Pooler Amy M AM Phillips Emma C EC Lau Dawn H W DH Noble Wendy W Hanger Diane P DP
EMBO reports 20130215 4
Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation of extracellular tau appears reduced in comparison with intracellular tau. We also find that AMPA-induced release of tau is calcium-dependent. Blocking pre-synaptic vesicle release by tetanus tox ...[more]