Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
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ABSTRACT:
SUBMITTER: Harley IT
PROVIDER: S-EPMC2737697 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
Harley Isaac T W IT Kaufman Kenneth M KM Langefeld Carl D CD Harley John B JB Kelly Jennifer A JA
Nature reviews. Genetics 20090501 5
Genome-wide association studies and fine mapping of candidate regions have rapidly advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE). More than 20 robust associations have now been identified and confirmed, providing insights at the molecular level that refine our understanding of the involvement of host immune response processes. In addition, genes with unknown roles in SLE pathophysiology have been identified. These findings may provide new routes towards im ...[more]
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