Is protein classification necessary? Toward alternative approaches to function annotation.
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ABSTRACT:
SUBMITTER: Petrey D
PROVIDER: S-EPMC2745633 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Is protein classification necessary? Toward alternative approaches to function annotation.
Current opinion in structural biology 20090305 3
The current nonredundant protein sequence database contains over seven million entries and the number of individual functional domains is significantly larger than this value. The vast quantity of data associated with these proteins poses enormous challenges to any attempt at function annotation. Classification of proteins into sequence and structural groups has been widely used as an approach to simplifying the problem. In this article we question such strategies. We describe how the multifunct ...[more]
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