Ontology highlight
ABSTRACT:
SUBMITTER: Harvey CD
PROVIDER: S-EPMC2745709 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20080612 5885
In neurons, individual dendritic spines isolate N-methyl-d-aspartate (NMDA) receptor-mediated calcium ion (Ca2+) accumulations from the dendrite and other spines. However, the extent to which spines compartmentalize signaling events downstream of Ca2+ influx is not known. We combined two-photon fluorescence lifetime imaging with two-photon glutamate uncaging to image the activity of the small guanosine triphosphatase Ras after NMDA receptor activation at individual spines. Induction of long-term ...[more]