Ontology highlight
ABSTRACT:
SUBMITTER: Andersen SL
PROVIDER: S-EPMC2746756 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Andersen Sabrina L SL Bergstralh Daniel T DT Kohl Kathryn P KP LaRocque Jeannine R JR Moore Chris B CB Sekelsky Jeff J
Molecular cell 20090701 1
DNA recombination and repair pathways require structure-specific endonucleases to process DNA structures that include forks, flaps, and Holliday junctions. Previously, we determined that the Drosophila MEI-9-ERCC1 endonuclease interacts with the MUS312 protein to produce meiotic crossovers, and that MUS312 has a MEI-9-independent role in interstrand crosslink (ICL) repair. The importance of MUS312 to pathways crucial for maintaining genomic stability in Drosophila prompted us to search for ortho ...[more]