Ontology highlight
ABSTRACT:
SUBMITTER: Fei J
PROVIDER: S-EPMC2747183 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Fei Jingyi J Bronson Jonathan E JE Hofman Jake M JM Srinivas Rathi L RL Wiggins Chris H CH Gonzalez Ruben L RL
Proceedings of the National Academy of Sciences of the United States of America 20090827 37
Determining the mechanism by which tRNAs rapidly and precisely transit through the ribosomal A, P, and E sites during translation remains a major goal in the study of protein synthesis. Here, we report the real-time dynamics of the L1 stalk, a structural element of the large ribosomal subunit that is implicated in directing tRNA movements during translation. Within pretranslocation ribosomal complexes, the L1 stalk exists in a dynamic equilibrium between open and closed conformations. Binding of ...[more]