Ontology highlight
ABSTRACT:
SUBMITTER: Buzzeo MC
PROVIDER: S-EPMC2747513 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Buzzeo Marisa C MC Barton Jacqueline K JK
Bioconjugate chemistry 20081101 11
Redmond Red, a fluoropore containing a redox-active phenoxazine core, has been explored as a new electrochemical probe for the detection of abasic sites in double-stranded DNA. The electrochemical behavior of Redmond Red-modified DNA at gold surfaces exhibits stable, quasi-reversible voltammetry with a midpoint potential centered around -50 mV versus NHE. Importantly, with Redmond Red positioned opposite an abasic site within the DNA duplex, the electrochemical response is significantly enhanced ...[more]