Ontology highlight
ABSTRACT:
SUBMITTER: Boynton AN
PROVIDER: S-EPMC5516787 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Inorganic chemistry 20170628 14
[Ru(bpy)<sub>2</sub>(BNIQ)]<sup>2+</sup> (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base ...[more]