Ontology highlight
ABSTRACT:
SUBMITTER: Pedersen IM
PROVIDER: S-EPMC2748825 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Pedersen Irene M IM Cheng Guofeng G Wieland Stefan S Volinia Stefano S Croce Carlo M CM Chisari Francis V FV David Michael M
Nature 20071001 7164
RNA interference through non-coding microRNAs (miRNAs) represents a vital component of the innate antiviral immune response in plants and invertebrate animals; however, a role for cellular miRNAs in the defence against viral infection in mammalian organisms has thus far remained elusive. Here we show that interferon beta (IFNbeta) rapidly modulates the expression of numerous cellular miRNAs, and that eight of these IFNbeta-induced miRNAs have sequence-predicted targets within the hepatitis C vir ...[more]