Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5545807 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Journal of molecular biology 20170623 16
How structural dynamics affects cytokine signaling is under debate. Here, we investigated the dynamics of the type I interferon (IFN) receptor, IFNAR1, and its effect on signaling upon binding IFN and IFNAR2 using a combination of structure-based mechanistic studies, in situ binding, and gene induction assays. Our study reveals that IFNAR1 flexibility modulates ligand-binding affinity, which, in turn, regulates biological signaling. We identified the hinge sites and key interactions implicated i ...[more]