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Condensation reactions to form oxazoline-substituted potassium organotrifluoroborates.

ABSTRACT: A library of oxazoline-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with tosylmethyl isocyanide under basic conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl bromides was achieved in good yields. The method allows the facile preparation of oxazole-containing triaromatic products in two steps from simple potassium formyl-substituted aryl- or heteroaryltrifluoroborates.

SUBMITTER: Molander GA

PROVIDER: S-EPMC2749650 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Condensation reactions to form oxazoline-substituted potassium organotrifluoroborates.

Molander Gary A GA Febo-Ayala Wilma W Jean-Gérard Ludivine L

Organic letters 20090901 17

A library of oxazoline-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with tosylmethyl isocyanide under basic conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl bromides was achieved in good yields. The method allows the facile preparation of oxazole-containing triaromatic products in two steps from simple potassium formyl-substituted aryl- or ...[more]

PMID: 19708697

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