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Copper-mediated radical trifluoromethylation of unsaturated potassium organotrifluoroborates.

ABSTRACT: Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields.

SUBMITTER: Presset M

PROVIDER: S-EPMC3886853 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Copper-mediated radical trifluoromethylation of unsaturated potassium organotrifluoroborates.

Presset Marc M Oehlrich Daniel D Rombouts Frederik F Molander Gary A GA

The Journal of organic chemistry 20131119 24

Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields. ...[more]

PMID: 24251623

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