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Thymic low affinity/avidity interaction selects natural Th1 cells.

ABSTRACT: Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There is additional evidence that this type of Eomes(+) innate CD4 T cell is also present in human cord blood.

SUBMITTER: Kang BH

PROVIDER: S-EPMC4456632 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Thymic low affinity/avidity interaction selects natural Th1 cells.

Kang Byung Hyun BH Park Hyo Jin HJ Yum Hye In HI Park Seung Pyo SP Park Jin Kyun JK Kang Eun Ha EH Lee Jae-Il JI Lee Eun Bong EB Park Chung-Gyu CG Jung Kyeong Cheon KC Park Seong Hoe SH

Journal of immunology (Baltimore, Md. : 1950) 20150513 12

Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high suscept ...[more]

PMID: 25972479

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