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Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

ABSTRACT: This paper describes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phenyl-1-butene via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination.

SUBMITTER: Fu R

PROVIDER: S-EPMC2752905 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

Fu Renzhong R Zhao Baoguo B Shi Yian Y

The Journal of organic chemistry 20091001 19

This paper describes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phenyl-1-butene via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination. ...[more]

PMID: 19778085

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