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Catalytic asymmetric allylic and homoallylic diamination of terminal olefins via formal C-H activation.


ABSTRACT: This paper describes a catalytic asymmetric diamination process for terminal olefins at allylic and homoallylic carbons via formal C-H activation using di-tert-butyldiaziridinone as nitrogen source with a catalyst generated from Pd2(dba)3 and chiral phosphorus amidite ligand. A wide variety of readily available terminal olefins can be effectively diaminated in good yields with high regio-, diastereo-, and enantioselectivities.

SUBMITTER: Du H 

PROVIDER: S-EPMC2776772 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Catalytic asymmetric allylic and homoallylic diamination of terminal olefins via formal C-H activation.

Du Haifeng H   Zhao Baoguo B   Shi Yian Y  

Journal of the American Chemical Society 20080613 27


This paper describes a catalytic asymmetric diamination process for terminal olefins at allylic and homoallylic carbons via formal C-H activation using di-tert-butyldiaziridinone as nitrogen source with a catalyst generated from Pd2(dba)3 and chiral phosphorus amidite ligand. A wide variety of readily available terminal olefins can be effectively diaminated in good yields with high regio-, diastereo-, and enantioselectivities. ...[more]

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