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Pd(0)-catalyzed 1,1-diarylation of ethylene and allylic carbonates.

ABSTRACT: An efficient protocol for the one-step synthesis of biologically relevant 1,1-diarylalkanes has been described. This reaction introduces two different aryl groups across the terminal end of simple feedstock alkenes such as ethylene and allylic carbonates. The propensity to generate ?-benzylpalladium intermediates dictates the exclusive 1,1-regioselectivity observed in the product.

SUBMITTER: Saini V

PROVIDER: S-EPMC3955058 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Pd(0)-catalyzed 1,1-diarylation of ethylene and allylic carbonates.

Saini Vaneet V Liao Longyan L Wang Qiaofeng Q Jana Ranjan R Sigman Matthew S MS

Organic letters 20130918 19

An efficient protocol for the one-step synthesis of biologically relevant 1,1-diarylalkanes has been described. This reaction introduces two different aryl groups across the terminal end of simple feedstock alkenes such as ethylene and allylic carbonates. The propensity to generate π-benzylpalladium intermediates dictates the exclusive 1,1-regioselectivity observed in the product. ...[more]

PMID: 24047468

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