Ontology highlight
ABSTRACT:
SUBMITTER: Alatwi HE
PROVIDER: S-EPMC4552491 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Alatwi Hanan E HE Downs Jessica A JA
EMBO reports 20150703 8
The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers. H2A.Z is actively incorporated at sites of damage in mammalian cells, raising the possibility that H2A.Z may need to be subsequently removed for resolution of repair. Here, we show that H2A.Z in human cells is indeed rapidly removed from chromatin flanking DNA dam ...[more]