Ontology highlight
ABSTRACT:
SUBMITTER: Stuven T
PROVIDER: S-EPMC275422 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Stüven Theis T Hartmann Enno E Görlich Dirk D
The EMBO journal 20031101 21
Active macromolecular transport between the nucleus and cytoplasm proceeds through nuclear pore complexes and is mostly mediated by transport receptors of the importin beta-superfamily. Here we identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes. Exp6 appears to contact primarily actin, but the interaction is greatly enhanced by the presence of profilin. Profilin thus functions not only as the nucleotide ...[more]