Ontology highlight
ABSTRACT:
SUBMITTER: Takeiwa T
PROVIDER: S-EPMC4418401 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Takeiwa Toshihiko T Taniguchi Ichiro I Ohno Mutsuhito M
Genes to cells : devoted to molecular & cellular mechanisms 20150204 4
The signal recognition particle is a ribonucleoprotein complex that is essential for the translocation of nascent proteins into the endoplasmic reticulum. It has been shown that the RNA component (SRP RNA) is exported from the nucleus by CRM1 in the budding yeast. However, how SRP RNA is exported in higher species has been elusive. Here, we show that SRP RNA does not use the CRM1 pathway in Xenopus oocytes. Instead, SRP RNA uses the same export pathway as pre-miRNA and tRNA as showed by cross-co ...[more]