Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2754317 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090901 35
We report a concise, enantioselective, and highly efficient synthesis of the marine actinomycete-derived natural product saliniketal B. Our approach was motivated with an eye toward future structure-function studies of this inhibitor of phorbol ester-mediated ornithine decarboxylase induction via an unknown mechanism. Our strategy highlights the utility of Pt(II)-mediated cycloisomerization of alkynediols developed in our laboratory to construct the dioxabicyclo[3.2.1]octane ring system, a highl ...[more]