Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC7248474 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Molecular medicine reports 20200428 1
Mammalian STE20-like kinase 1 (MST1) plays an important role in pancreatic cancer progression, but its downstream targets are still unknown. In the present study, our results indicated that MST1 expression was significantly downregulated in pancreatic cancer cell lines (PANC‑1, BxPC‑3 and HPAC) compared with that in the normal ductal epithelial cell line (hTERT‑HPNE). Moreover, MST1 overexpression in PANC‑1 cells led to increased apoptosis as determined by MTT and TUNEL assays and inhibited cell ...[more]