Ontology highlight
ABSTRACT:
SUBMITTER: Galan B
PROVIDER: S-EPMC275547 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20031101 22
The HpaR-mediated regulation of the hpa-meta operon (Pg promoter) of the 4-hydroxyphenylacetic acid catabolic pathway of Escherichia coli has been studied. The HpaR regulator was purified to homogeneity showing that it is able to bind selectively to 4-hydroxyphenylacetic, 3-hydroxyphenylacetic and 3,4-dihydroxyphenylacetic acids, which act as inducers of the system. The role of HpaR as a repressor and the requirement for cAMP receptor protein for maximal activity have been confirmed by in vitro ...[more]