Ontology highlight
ABSTRACT:
SUBMITTER: Fischer SE
PROVIDER: S-EPMC2756026 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Fischer Sylvia E J SE Butler Maurice D MD Pan Qi Q Ruvkun Gary G
Nature 20080910 7212
Mutations that enhance the response to double-stranded RNA (dsRNA) have revealed components of the RNA interference (RNAi) pathway or related small RNA pathways. To explore these small RNA pathways, we screened for Caenorhabditis elegans mutants displaying an enhanced response to exogenous dsRNAs. Here we describe the isolation of mutations in two adjacent, divergently transcribed open reading frames (eri-6 and eri-7) that fail to complement. eri-6 and eri-7 produce separate pre-messenger RNAs ( ...[more]