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The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

ABSTRACT: The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

SUBMITTER: Gabel HW

PROVIDER: S-EPMC2910399 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Gabel Harrison W HW Ruvkun Gary G

Nature structural & molecular biology 20080427 5

The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. ...[more]

PMID: 18438419

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