Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer.
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ABSTRACT:
SUBMITTER: Merz AL
PROVIDER: S-EPMC2756767 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer.
Merz Andrea L AL Serkova Natalie J NJ
Biomarkers in medicine 20090601 3
Cancer cells possess a highly unique metabolic phenotype, which is characterized by high glucose uptake, increased glycolytic activity, decreased mitochondrial activity, low bioenergetic and increased phospholipid turnover. These metabolic hallmarks can be readily assessed by metabolic technologies - either in vitro or in vivo - to monitor responsiveness and resistance to novel targeted drugs, where specific inhibition of cell proliferation (cytostatic effect) occurs rather than direct induction ...[more]
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