Connexins are critical for normal myelination in the CNS.
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ABSTRACT:
SUBMITTER: Menichella DM
PROVIDER: S-EPMC6741267 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Publications
Connexins are critical for normal myelination in the CNS.
Menichella Daniela M DM Goodenough Daniel A DA Sirkowski Erich E Scherer Steven S SS Paul David L DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030701 13
Mutations in Cx32, a gap-junction channel-forming protein, result in X-linked Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system. However, although oligodendrocytes express Cx32, central myelination is unaffected. To explore this discrepancy, we searched for additional oligodendrocyte connexins. We found Cx47, which is expressed specifically in oligodendrocytes, regulated in parallel with myelin genes and partially colocalized with Cx32 in oligodendrocytes. Mic ...[more]
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