Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC2757630 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Yang Huanghao H Liu Haipeng H Kang Huaizhi H Tan Weihong W
Journal of the American Chemical Society 20080429 20
In this communication, we report a simple, but highly adaptable, method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. In this design, competitive binding of target to the aptamer causes the decrease of cross-linking density and, hence, dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was ...[more]