Comparative analysis of the mammalian WNT4 promoter.
Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC2758904 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Comparative analysis of the mammalian WNT4 promoter.
Yu Hongshi H Pask Andrew J AJ Shaw Geoffrey G Renfree Marilyn B MB
BMC genomics 20090906
<h4>Background</h4>WNT4 is a critical signalling molecule in embryogenesis and homeostasis, but the elements that control its transcriptional regulation are largely unknown. This study uses comparative cross species sequence and functional analyses between humans and a marsupial (the tammar wallaby,Macropus eugenii) to refine the mammalian Wnt4 promoter.<h4>Results</h4>We have defined a highly conserved 89 bp minimal promoter region in human WNT4 by comparative analysis with the tammar wallaby. ...[more]
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