Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC2758918 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20090913 10
Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-A resolution structure of the zinc transporter YiiP from Escherichia coli reveals a richly charged dimer interface stabilized by zinc binding. Site-directed fluorescence resonance energy transfer (FRET) measurements and mutation-activity analysis suggest that zinc binding triggers hinge movements of two electrically repulsive cytoplasmic domains pivoting around four salt bridges situated at the juncture of the cyt ...[more]