Ontology highlight
ABSTRACT:
SUBMITTER: Miyauchi H
PROVIDER: S-EPMC5696359 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171121 1
Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the excretion of xenobiotics and cationic clinical drugs, whereas some plant MATE transporters are responsible for aluminum tolerance and secondary metabolite transport. Here we report the crystal structure of the eukaryotic MATE transporter from Arabidopsis thaliana, at 2.6 Å resolution. The structure reveals that its carboxy-terminal lobe ( ...[more]