Ontology highlight
ABSTRACT:
SUBMITTER: Thibodeau J
PROVIDER: S-EPMC2759377 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
European journal of immunology 20080501 5
IL-10 is a potent anti-inflammatory cytokine interfering with antigen presentation by inducing the intracellular sequestration of MHC class II (MHC-II) molecules. Here we studied the contribution of membrane-associated RING-CH (MARCH) ubiquitin ligase family members to the IL-10-induced down-regulation of MHC-II molecules. We found that MARCH1 and MARCH8 proteins are the most potent family members for the down-regulation of MHC-II surface expression in transfected cells, but only MARCH1 mRNA exp ...[more]