Ontology highlight
ABSTRACT:
SUBMITTER: Wilson KR
PROVIDER: S-EPMC6042767 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wilson Kayla R KR Liu Haiyin H Healey Geraldine G Vuong Vivian V Ishido Satoshi S Herold Marco J MJ Villadangos Jose A JA Mintern Justine D JD
PloS one 20180712 7
Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I. Lack of MARCH1 in B cells and dendritic cells (DCs) resulted in a significant reduction in surface MHC I expression. This decrease was not directly caused by changes in MARCH1 ubiquitination of MHC I but indirectly by altered MHC II trafficking in the absence o ...[more]