Ontology highlight
ABSTRACT:
SUBMITTER: Sundqvist A
PROVIDER: S-EPMC2759733 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Sundqvist Anders A Liu Geng G Mirsaliotis Antonis A Xirodimas Dimitris P DP
EMBO reports 20090828 10
Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin-like molecule NEDD8, and that NEDDylation protects RPs from destabilization. Here, we identify NEDD8 as a crucial regulator of L11 RP signalling to p53. A decrease in L11 NEDDylation during nucleolar stress cause ...[more]