Ontology highlight
ABSTRACT:
SUBMITTER: Tian B
PROVIDER: S-EPMC2760486 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Tian Bo B Yang Qian Q Mao Zixu Z
Nature cell biology 20090118 2
The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. However, the mechanism by which DNA damage activates ATM is poorly understood. Here we show that Cdk5 (cyclin-dependent kinase 5), activated by DNA damage, directly phosphorylates ATM at Ser 7 ...[more]