Ontology highlight
ABSTRACT:
SUBMITTER: Cemerski S
PROVIDER: S-EPMC2763191 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Cemerski Saso S Das Jayajit J Locasale Jason J Arnold Phoebe P Giurisato Emanuele E Markiewicz Mary A MA Fremont Daved D Allen Paul M PM Chakraborty Arup K AK Shaw Andrey S AS
Immunity 20070308 3
T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results showing that a peptide exhibiting many hallmarks of a weak agonist stimulates T cells to proliferate more than the wild-type agonist ligand. An in silico approach suggested that the inability to form the central supramolecular activation cluster (cSMAC) could un ...[more]