Ontology highlight
ABSTRACT:
SUBMITTER: Lell B
PROVIDER: S-EPMC2763199 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Lell Bertrand B Agnandji Selidji S von Glasenapp Isabelle I Haertle Sonja S Oyakhiromen Sunny S Issifou Saadou S Vekemans Johan J Leach Amanda A Lievens Marc M Dubois Marie-Claude MC Demoitie Marie-Ange MA Carter Terrell T Villafana Tonya T Ballou W Ripley WR Cohen Joe J Kremsner Peter G PG
PloS one 20091027 10
<h4>Background</h4>The malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant Systems are in development for this vaccine, an oil-in water emulsion--based formulation (AS02) and a formulation based on liposomes (AS01).<h4>Methods & principal findings</h4>In this Phase II, double-blind study (NCT00307021), 180 healthy Gabonese children aged 18 months to 4 years were randomized to receive ...[more]