Ontology highlight
ABSTRACT:
SUBMITTER: Vora T
PROVIDER: S-EPMC2763621 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20090701 2
Protein-DNA interactions are fundamental to core biological processes, including transcription, DNA replication, and chromosomal organization. We have developed in vivo protein occupancy display (IPOD), a technology that reveals protein occupancy across an entire bacterial chromosome at the resolution of individual binding sites. Application to Escherichia coli reveals thousands of protein occupancy peaks, highly enriched within and in close proximity to noncoding regulatory regions. In addition ...[more]