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Aberrarone: a gorgonian-derived diterpene from Pseudopterogorgia elisabethae.

ABSTRACT: A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum.

SUBMITTER: Rodriguez II

PROVIDER: S-EPMC2764255 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Aberrarone: a gorgonian-derived diterpene from Pseudopterogorgia elisabethae.

Rodríguez Ileana I II Rodríguez Abimael D AD Zhao Hong H

The Journal of organic chemistry 20091001 19

A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum. ...[more]

PMID: 19736920

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