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Tin-free enantioselective radical reactions using silanes.

ABSTRACT: Readily available hexyl silane is an excellent choice as a H-atom donor and a chain carrier in Lewis acid mediated enantioselective radical reactions. Conjugate radical additions to alpha,beta-unsaturated imides at room temperature proceed in good yields and excellent enantioselectivities.

SUBMITTER: Sibi MP

PROVIDER: S-EPMC2765535 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Tin-free enantioselective radical reactions using silanes.

Sibi Mukund P MP Yang Yong-Hua YH Lee Sunggi S

Organic letters 20081201 23

Readily available hexyl silane is an excellent choice as a H-atom donor and a chain carrier in Lewis acid mediated enantioselective radical reactions. Conjugate radical additions to alpha,beta-unsaturated imides at room temperature proceed in good yields and excellent enantioselectivities. ...[more]

PMID: 18986157

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