Ontology highlight
ABSTRACT:
SUBMITTER: Lea IA
PROVIDER: S-EPMC2768054 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Lea Isabel A IA Jackson Marcus A MA Dunnick June K JK
Mutation research 20090701 1-2
The colorectal cancer paradigm explains how genetic and histological changes lead normal epithelial cell to transform into pre-malignant adenomas then progress to malignant carcinomas. Using the Genetic Alterations in Cancer Knowledge System intragenic allele loss and gene mutation data from approximately 9000 colorectal tumors were compared to the model of colorectal tumor development. The distribution of mutations along the TP53 codons as a function of tumorigenesis also was analyzed. Alterati ...[more]