Ontology highlight
ABSTRACT:
SUBMITTER: Lucas HR
PROVIDER: S-EPMC2880511 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Lucas Heather R HR Debeer Serena S Hong Myoung-Soon MS Lee Jennifer C JC
Journal of the American Chemical Society 20100501 19
Alpha-synuclein (alpha-syn), a presynaptic protein implicated in Parkinson's disease, binds copper(II) ion (1:1) with submicromolar affinity in vitro. Insights on the molecular details of soluble- and fibrillar-Cu-alpha-syn are gained through X-ray absorption spectroscopy. Our results indicate that the copper coordination environment (3-to-4 N/O ligands, average Cu-ligand distance approximately 1.96 A) exhibits little structural rearrangement upon amyloid formation in spite of the overall polype ...[more]