Ontology highlight
ABSTRACT:
SUBMITTER: Hategan A
PROVIDER: S-EPMC5383535 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hategan Alina A Bianchet Mario A MA Steiner Joseph J Karnaukhova Elena E Masliah Eliezer E Fields Adam A Lee Myoung-Hwa MH Dickens Alex M AM Haughey Norman N Dimitriadis Emilios K EK Nath Avindra A
Nature structural & molecular biology 20170220 4
Deposition of amyloid-β plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein affects amyloidogenesis through several indirect mechanisms. Here, we investigated direct interactions between Tat and amyloid-β peptide. Our in vitro studies showed that in the presence of Tat, uniform amyloid fibrils become double twisted fibrils and further form populations of thick unstructured filaments and aggregates. Specifically, Tat binding to ...[more]